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Keitaro Hashimoto Selected Research

Halothane (Fluothane)

8/2008Torsades de pointes liability inter-model comparisons: the experience of the QT PRODACT initiative.
4/2007Arrhythmia models for drug research: classification of antiarrhythmic drugs.
4/2006Characterization of the halothane-anesthetized guinea-pig heart as a model to detect the K+ channel blocker-induced QT-interval prolongation.
10/2004Comparison of sensitivity of surrogate markers of drug-induced torsades de pointes in canine hearts.
6/2004Development of a halothane-adrenaline arrhythmia model using in vivo Guinea pigs.
5/2004Electropharmacological and proarrhythmic effects of a class III antiarrhythmic drug nifekalant hydrochloride assessed using the in vivo canine models.
2/2004In vivo experimental approach for the risk assessment of fluoroquinolone antibacterial agents-induced long QT syndrome.
8/2003Effects of mexiletine on the canine model of sparfloxacin-induced long QT syndrome.
8/2002Torsadegenic action of the antipsychotic drug sulpiride assessed using in vivo canine models.

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Keitaro Hashimoto Research Topics

Disease

12Atrioventricular Block
08/2008 - 03/2002
11Cardiac Arrhythmias (Arrythmia)
03/2011 - 09/2003
10Torsades de Pointes (Torsade de Pointes)
08/2008 - 04/2002
8Ventricular Fibrillation
03/2011 - 01/2002
7Long QT Syndrome
02/2007 - 09/2002
6Ischemia
03/2007 - 01/2002
5Bradycardia
03/2011 - 05/2004
4Coronary Occlusion
08/2008 - 01/2002
3Heart Failure
07/2007 - 12/2002
3Ventricular Tachycardia
09/2005 - 04/2002
3Tachycardia (Tachyarrhythmias)
01/2005 - 05/2002
2Myocardial Infarction
04/2007 - 09/2003
2Ventricular Premature Complexes (Premature Ventricular Contraction)
06/2004 - 05/2002
1Body Weight (Weight, Body)
03/2007
1Hypokalemia
01/2006
1Myocardial Ischemia (Ischemic Heart Diseases)
08/2005
1Cardiac Sudden Death (Sudden Cardiac Arrest)
08/2005
1Atrial Fibrillation
05/2005
1Hypertension (High Blood Pressure)
05/2005
1Premature Cardiac Complexes (Extrasystoles)
01/2005
1Gastrointestinal Diseases (Functional Gastrointestinal Disorders)
09/2003
1Drug Overdose
04/2003
1Kidney Diseases (Kidney Disease)
01/2003
1Syncope (Fainting)
08/2002
1Heart Arrest (Cardiac Arrest)
07/2002

Drug/Important Bio-Agent (IBA)

11Pharmaceutical PreparationsIBA
07/2007 - 03/2002
9Halothane (Fluothane)FDA Link
08/2008 - 08/2002
5Anti-Arrhythmia AgentsIBA
03/2011 - 01/2004
3Epinephrine (Adrenaline)FDA LinkGeneric
08/2008 - 06/2004
3nifekalantIBA
02/2007 - 05/2004
3sparfloxacin (AT 4140)FDA Link
01/2006 - 08/2003
2Terfenadine (Seldane)IBA
08/2008 - 03/2006
2Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
03/2007 - 09/2003
2FluvastatinFDA Link
03/2007 - 09/2003
2Pravastatin (Pravachol)FDA LinkGeneric
03/2007 - 09/2003
2CholesterolIBA
03/2007 - 09/2003
2methanesulfonic acid (methanesulfonate)IBA
08/2005 - 11/2002
2Pentobarbital (Nembutal)FDA Link
08/2005 - 11/2002
2cilnidipineIBA
05/2005 - 10/2004
2Amiodarone (Amiodarona)FDA LinkGeneric
03/2005 - 08/2002
2Mexiletine (Mexitil)FDA LinkGeneric
01/2004 - 08/2003
2SodiumIBA
09/2003 - 11/2002
2sematilideIBA
08/2002 - 04/2002
1Ion Channels (Ion Channel)IBA
03/2011
1salicylhydroxamic acid (SHAM)IBA
07/2007
1Peroxidase (Myeloperoxidase)IBA
03/2007
1Sodium Channels (Sodium Channel)IBA
09/2006
1PotassiumIBA
09/2006
1Histamine (Histamine Dihydrochloride)FDA Link
03/2006
1Sotalol (Sotalol Hydrochloride)FDA LinkGeneric
10/2005
1Magnesium Hydroxide (Brucite)FDA Link
09/2005
1MagnesiumIBA
09/2005
1Guanidine (Guanidine Nitrate)FDA Link
08/2005
1N- (4- isopropyl- 2,2- dimethyl- 3- oxo- 3,4- dihydro- 2H- benzo(1,4)oxazine- 6- carbonyl)guanidineIBA
08/2005
1Sodium-Hydrogen ExchangersIBA
08/2005
11,4-dihydropyridine (dihydropyridine)IBA
05/2005
1Calcium Channel Blockers (Blockers, Calcium Channel)IBA
05/2005
1N-Type Calcium Channels (N-Type Calcium Channel)IBA
05/2005
1SEA 0400IBA
01/2005
1Prochlorperazine (Compazine)FDA LinkGeneric
01/2005
1Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA
12/2004
1Spironolactone (Aldactone)FDA LinkGeneric
12/2004
1Ether (Diethyl Ether)IBA
12/2004
1Biomarkers (Surrogate Marker)IBA
10/2004
1CatecholaminesIBA
10/2004
1Diltiazem (Cardizem)FDA LinkGeneric
06/2004
1ChloraloseIBA
02/2004
1Gatifloxacin (Zymar)FDA Link
02/2004
1Moxifloxacin (Avelox)FDA Link
02/2004
1Methoxamine (Methoxamine Hydrochloride)FDA Link
02/2004
1sitafloxacinIBA
02/2004
1FluoroquinolonesIBA
02/2004
1Anti-Bacterial Agents (Antibiotics)IBA
02/2004
1Disopyramide (Norpace)FDA LinkGeneric
01/2004
1Flecainide (Tambocor)FDA LinkGeneric
01/2004
1Procainamide (Procan)FDA LinkGeneric
01/2004
1daisaikotoIBA
09/2003
1Glyburide (Glibenclamide)FDA LinkGeneric
09/2003
1Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
09/2003
1SaltsIBA
09/2003
1Adenosine Triphosphate (ATP)IBA
09/2003
1sairei-toIBA
09/2003
1sannoshashintoIBA
09/2003
1Cardiotonic Agents (Cardiac Stimulants)IBA
04/2003
1Famotidine (Pepcid)FDA LinkGeneric
04/2003
14,4'- Diisothiocyanostilbene- 2,2'- Disulfonic Acid (DIDS)IBA
01/2003
14- Acetamido- 4'- isothiocyanatostilbene- 2,2'- disulfonic Acid (SITS)IBA
01/2003
1potassium bromideIBA
01/2003
1Adrenergic Receptors (Adrenergic Receptor)IBA
12/2002
1colforsin daropateIBA
12/2002
1Sodium-Calcium ExchangerIBA
11/2002
12- (2- (4- (4- nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonateIBA
11/2002
1Sulpiride (neogama)IBA
08/2002

Therapy/Procedure

3Ligation
04/2007 - 01/2005
3Therapeutics
09/2005 - 08/2002
1Defibrillators (Defibrillator)
03/2011
1Anesthesia
10/2005
1Aftercare (After-Treatment)
09/2005
1Oral Administration
02/2004
1Kampo Medicine (Kampo)
09/2003